p53 (proteína): funciones, ciclo celular y enfermedades, Estructura de la proteína p53 (Fuente: Protein Data Bank.
[31] Studies of human embryonic stem cells (hESCs) commonly describe the nonfunctional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). A considerable number of mutant p53 proteins probably have an oncogenic activity per se and therefore actively participate in cell transformation. mutation spectrum in breast cancer is subtype specific and has distinct
Epub 2012 Mar 4.
La proteína p53 puede regular una variedad de procesos celulares de manera positiva o negativa, manteniendo la homeostasis en condiciones estándar.
Regulators of Oncogenic Mutant TP53 Gain of Function. Recent research has shown that HAUSP is mainly localized in the nucleus, though a fraction of it can be found in the cytoplasm and mitochondria. This is one means by which p53 is stabilized in response to oncogenic insults. Available from: GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity, core promoter sequence-specific DNA binding, GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription factor binding, GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II regulatory region sequence-specific DNA binding, GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding, positive regulation of histone deacetylation, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of telomerase activity, positive regulation of neuron apoptotic process, regulation of mitochondrial membrane permeability, positive regulation of reactive oxygen species metabolic process, positive regulation of thymocyte apoptotic process, negative regulation of cell proliferation, regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of fibroblast proliferation, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, DNA damage response, signal transduction by p53 class mediator, oxidative stress-induced premature senescence, positive regulation of release of cytochrome c from mitochondria, negative regulation of transcription, DNA-templated, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of execution phase of apoptosis, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, positive regulation of protein oligomerization, entrainment of circadian clock by photoperiod, positive regulation of transcription from RNA polymerase II promoter, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, regulation of cell cycle G2/M phase transition, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of signal transduction by p53 class mediator, transcription from RNA polymerase II promoter, positive regulation of protein export from nucleus, negative regulation of transcription from RNA polymerase II promoter, positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, RNA polymerase II transcriptional preinitiation complex assembly, signal transduction by p53 class mediator, positive regulation of pri-miRNA transcription from RNA polymerase II promoter, positive regulation of production of miRNAs involved in gene silencing by miRNA, release of cytochrome c from mitochondria, hematopoietic progenitor cell differentiation, T cell proliferation involved in immune response, transforming growth factor beta receptor signaling pathway, negative regulation of neuroblast proliferation, embryo development ending in birth or egg hatching, positive regulation of cardiac muscle cell apoptotic process, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of mitochondrial membrane permeability, positive regulation of transcription from RNA polymerase II promoter in response to stress, regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of mitotic cell cycle, interferon-gamma-mediated signaling pathway, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of programmed necrotic cell death, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, regulation of thymocyte apoptotic process, regulation of mitochondrial membrane permeability involved in apoptotic process, regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of production of miRNAs involved in gene silencing by miRNA, negative regulation of glucose catabolic process to lactate via pyruvate, intrinsic apoptotic signaling pathway in response to hypoxia, regulation of fibroblast apoptotic process, negative regulation of reactive oxygen species metabolic process, loss-of-function or gain-of-function mutations, double-stranded breaks (DSB) or UV radiation, GRCh38: Ensembl release 89: ENSG00000141510, GRCm38: Ensembl release 89: ENSMUSG00000059552, "The Guardian of the Genome Revisited: P53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure", "Uncovering the role of p53 splice variants in human malignancy: a clinical perspective", "Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene", "The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13)", "p53 isoforms can regulate p53 transcriptional activity", "Cell-free translations of proline-rich protein mRNAs", "Twenty years of p53 research: structural and functional aspects of the p53 protein", "OrthoMaM phylogenetic marker: TP53 coding sequence", "TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers", "Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck", "The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression", "The C terminus of p53 family proteins is a cell fate determinant", "Central role of p53 in the suntan response and pathologic hyperpigmentation", "p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells", "Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells", "Critical role for P53 in regulating the cell cycle of ground state embryonic stem cells", "HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells", "Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma", "A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity", "Regulation of p53 is critical for vertebrate limb regeneration", "p53 inhibits angiogenesis by inducing the production of Arresten", "The in vivo gene expression signature of oxidative stress", "MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53", "Regulation of p53 stability and function by the deubiquitinating enzyme USP42", "USP10 regulates p53 localization and stability by deubiquitinating p53", "Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice", "Dissecting p53 tumor suppressor functions in vivo", "Visualization and targeted disruption of protein interactions in living cells", "Thermodynamic stability of wild-type and mutant p53 core domain", "p53-dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cells", "Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells", "Scientists identify drugs to target 'Achilles heel' of Chronic Myeloid Leukaemia cells", "p53 Isoforms: An Intracellular Microprocessor?
[35], In adult stem cells, p53 regulation is important for maintenance of stemness in adult stem cell niches. p21 can also mediate growth arrest associated with differentiation and a more permanent growth arrest associated with cellular senescence. doi: 10.1101/cshperspect.a001008. Erratum in: Clin Cancer Res.
Persistent infection of the cervix over the years can cause irreversible changes leading to carcinoma in situ and eventually invasive cervical cancer. (2015).
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